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mso-style-qformat:yes; mso-style-link:"Párrafo de lista Car\,PDrrafo de lista Car\,Párrafo de lista1 Car"; mso-style-type:export-only; margin-top:0cm; margin-right:0cm; margin-bottom:0cm; margin-left:36.0pt; margin-bottom:.0001pt; mso-add-space:auto; line-height:105%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:ES; mso-fareast-language:EN-US;} p.MsoListParagraphCxSpLast, li.MsoListParagraphCxSpLast, div.MsoListParagraphCxSpLast {mso-style-name:"Párrafo de lista\,PDrrafo de lista\,Párrafo de lista1CxSpLast"; mso-style-priority:34; mso-style-unhide:no; mso-style-qformat:yes; mso-style-link:"Párrafo de lista Car\,PDrrafo de lista Car\,Párrafo de lista1 Car"; mso-style-type:export-only; margin-top:0cm; margin-right:0cm; margin-bottom:8.0pt; margin-left:36.0pt; mso-add-space:auto; line-height:105%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:ES; mso-fareast-language:EN-US;} p.MsoQuote, li.MsoQuote, div.MsoQuote {mso-style-noshow:yes; mso-style-priority:29; mso-style-unhide:no; mso-style-qformat:yes; mso-style-link:"Cita Car"; mso-style-next:Normal; margin-top:0cm; margin-right:0cm; margin-bottom:0cm; margin-left:14.2pt; margin-bottom:.0001pt; text-align:justify; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Arial",sans-serif; mso-fareast-font-family:"Times New Roman"; color:black; mso-themecolor:text1; 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mso-style-next:Normal; margin-top:12.0pt; margin-right:0cm; margin-bottom:0cm; margin-left:0cm; margin-bottom:.0001pt; text-align:center; line-height:105%; mso-pagination:widow-orphan lines-together; page-break-after:avoid; font-size:16.0pt; font-family:"Calibri Light",sans-serif; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi; color:#2F5496; mso-themecolor:accent1; mso-themeshade:191; mso-ansi-language:ES; mso-fareast-language:ES;} span.Ttulo1Car {mso-style-name:"Título 1 Car"; mso-style-priority:9; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Título 1"; mso-ansi-font-size:24.0pt; mso-bidi-font-size:24.0pt; font-family:"Times New Roman",serif; mso-ascii-font-family:"Times New Roman"; mso-fareast-font-family:"Times New 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font-family:"Calibri Light",sans-serif; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi; color:#1F3763; mso-themecolor:accent1; mso-themeshade:127;} span.HTMLconformatoprevioCar {mso-style-name:"HTML con formato previo Car"; mso-style-noshow:yes; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"HTML con formato previo"; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; font-family:"Courier New"; mso-ascii-font-family:"Courier New"; mso-fareast-font-family:"Times New Roman"; mso-hansi-font-family:"Courier New"; mso-bidi-font-family:"Courier New"; mso-fareast-language:ES;} p.msonormal0, li.msonormal0, div.msonormal0 {mso-style-name:msonormal; mso-style-priority:99; mso-style-unhide:no; mso-margin-top-alt:auto; margin-right:0cm; mso-margin-bottom-alt:auto; margin-left:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-fareast-language:ES-EC;} span.TextonotapieCar {mso-style-name:"Texto nota pie Car"; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Texto nota pie"; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; font-family:"Times New Roman",serif; mso-ascii-font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-hansi-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman"; mso-ansi-language:EN-US;} span.TextocomentarioCar {mso-style-name:"Texto comentario Car"; mso-style-noshow:yes; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Texto comentario"; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} span.EncabezadoCar {mso-style-name:"Encabezado Car"; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:Encabezado;} span.PiedepginaCar {mso-style-name:"Pie de página Car"; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Pie de página";} span.SangradetextonormalCar {mso-style-name:"Sangría de texto normal Car"; mso-style-noshow:yes; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Sangría de texto normal"; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-fareast-font-family:"Times New Roman"; mso-hansi-font-family:Calibri; mso-bidi-font-family:"Times New Roman"; mso-ansi-language:X-NONE; mso-bidi-language:EN-US;} span.AsuntodelcomentarioCar {mso-style-name:"Asunto del comentario Car"; mso-style-noshow:yes; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-parent:"Texto comentario Car"; mso-style-link:"Asunto del comentario"; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; font-weight:bold;} span.TextodegloboCar {mso-style-name:"Texto de globo Car"; mso-style-noshow:yes; mso-style-priority:99; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Texto de globo"; mso-ansi-font-size:9.0pt; mso-bidi-font-size:9.0pt; font-family:"Times New Roman",serif; mso-ascii-font-family:"Times New Roman"; mso-hansi-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";} span.SinespaciadoCar {mso-style-name:"Sin espaciado Car"; mso-style-priority:1; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Sin espaciado"; font-family:"MS Mincho"; mso-ascii-font-family:"MS Mincho"; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:"MS Mincho"; mso-fareast-language:ES;} span.PrrafodelistaCar {mso-style-name:"Párrafo de lista Car\,PDrrafo de lista Car\,Párrafo de lista1 Car"; mso-style-priority:34; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Párrafo de lista\,PDrrafo de lista\,Párrafo de lista1";} span.CitaCar {mso-style-name:"Cita Car"; mso-style-priority:29; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:Cita; mso-ansi-font-size:12.0pt; mso-bidi-font-size:12.0pt; font-family:"Arial",sans-serif; mso-ascii-font-family:Arial; mso-fareast-font-family:"Times New Roman"; mso-hansi-font-family:Arial; mso-bidi-font-family:Arial; color:black; mso-themecolor:text1; mso-fareast-language:ES-EC; mso-bidi-font-style:italic;} p.xmsonormal, li.xmsonormal, div.xmsonormal {mso-style-name:x_msonormal; mso-style-noshow:yes; mso-style-priority:99; mso-style-unhide:no; mso-margin-top-alt:auto; margin-right:0cm; mso-margin-bottom-alt:auto; margin-left:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:ES; mso-fareast-language:ES;} span.ANGLESCar {mso-style-name:"ANGLES Car"; mso-style-unhide:no; mso-style-locked:yes; mso-style-parent:""; mso-style-link:ANGLES; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; 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font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.MsoTable15Grid4Accent1FirstRow {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 1"; mso-table-condition:first-row; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-shading:#4472C4; mso-tstyle-shading-themecolor:accent1; mso-tstyle-border-top:.5pt solid #4472C4; mso-tstyle-border-top-themecolor:accent1; mso-tstyle-border-left:.5pt solid #4472C4; mso-tstyle-border-left-themecolor:accent1; mso-tstyle-border-bottom:.5pt solid #4472C4; mso-tstyle-border-bottom-themecolor:accent1; mso-tstyle-border-right:.5pt solid #4472C4; mso-tstyle-border-right-themecolor:accent1; mso-tstyle-border-insideh:cell-none; mso-tstyle-border-insidev:cell-none; color:white; mso-themecolor:background1; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent1LastRow {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 1"; mso-table-condition:last-row; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-border-top:1.5pt double #4472C4; mso-tstyle-border-top-themecolor:accent1; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent1FirstCol {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 1"; mso-table-condition:first-column; mso-style-priority:49; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent1LastCol {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 1"; mso-table-condition:last-column; mso-style-priority:49; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent1OddColumn {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 1"; mso-table-condition:odd-column; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-shading:#D9E2F3; mso-tstyle-shading-themecolor:accent1; mso-tstyle-shading-themetint:51;} table.MsoTable15Grid4Accent1OddRow {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 1"; mso-table-condition:odd-row; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-shading:#D9E2F3; mso-tstyle-shading-themecolor:accent1; mso-tstyle-shading-themetint:51;} table.MsoTable15Grid6ColorfulAccent1 {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-tstyle-rowband-size:1; mso-tstyle-colband-size:1; mso-style-priority:51; mso-style-unhide:no; border:solid #8EAADB 1.0pt; mso-border-themecolor:accent1; mso-border-themetint:153; mso-border-alt:solid #8EAADB .5pt; mso-border-themecolor:accent1; mso-border-themetint:153; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-border-insideh:.5pt solid #8EAADB; mso-border-insideh-themecolor:accent1; mso-border-insideh-themetint:153; mso-border-insidev:.5pt solid #8EAADB; mso-border-insidev-themecolor:accent1; mso-border-insidev-themetint:153; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; color:#2F5496; mso-themecolor:accent1; mso-themeshade:191; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.MsoTable15Grid6ColorfulAccent1FirstRow {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-table-condition:first-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-border-bottom:1.5pt solid #8EAADB; mso-tstyle-border-bottom-themecolor:accent1; mso-tstyle-border-bottom-themetint:153; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid6ColorfulAccent1LastRow {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-table-condition:last-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-border-top:1.5pt double #8EAADB; mso-tstyle-border-top-themecolor:accent1; mso-tstyle-border-top-themetint:153; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid6ColorfulAccent1FirstCol {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-table-condition:first-column; mso-style-priority:51; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid6ColorfulAccent1LastCol {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-table-condition:last-column; mso-style-priority:51; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid6ColorfulAccent1OddColumn {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-table-condition:odd-column; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-shading:#D9E2F3; mso-tstyle-shading-themecolor:accent1; mso-tstyle-shading-themetint:51;} table.MsoTable15Grid6ColorfulAccent1OddRow {mso-style-name:"Tabla con cuadrícula 6 con colores - Énfasis 1"; mso-table-condition:odd-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-shading:#D9E2F3; mso-tstyle-shading-themecolor:accent1; mso-tstyle-shading-themetint:51;} table.MsoTable15Grid4Accent5 {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-tstyle-rowband-size:1; mso-tstyle-colband-size:1; mso-style-priority:49; mso-style-unhide:no; border:solid #9CC2E5 1.0pt; mso-border-themecolor:accent5; mso-border-themetint:153; mso-border-alt:solid #9CC2E5 .5pt; mso-border-themecolor:accent5; mso-border-themetint:153; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-border-insideh:.5pt solid #9CC2E5; mso-border-insideh-themecolor:accent5; mso-border-insideh-themetint:153; mso-border-insidev:.5pt solid #9CC2E5; mso-border-insidev-themecolor:accent5; mso-border-insidev-themetint:153; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.MsoTable15Grid4Accent5FirstRow {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-table-condition:first-row; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-shading:#5B9BD5; mso-tstyle-shading-themecolor:accent5; mso-tstyle-border-top:.5pt solid #5B9BD5; mso-tstyle-border-top-themecolor:accent5; mso-tstyle-border-left:.5pt solid #5B9BD5; mso-tstyle-border-left-themecolor:accent5; mso-tstyle-border-bottom:.5pt solid #5B9BD5; mso-tstyle-border-bottom-themecolor:accent5; mso-tstyle-border-right:.5pt solid #5B9BD5; mso-tstyle-border-right-themecolor:accent5; mso-tstyle-border-insideh:cell-none; mso-tstyle-border-insidev:cell-none; color:white; mso-themecolor:background1; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent5LastRow {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-table-condition:last-row; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-border-top:1.5pt double #5B9BD5; mso-tstyle-border-top-themecolor:accent5; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent5FirstCol {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-table-condition:first-column; mso-style-priority:49; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent5LastCol {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-table-condition:last-column; mso-style-priority:49; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15Grid4Accent5OddColumn {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-table-condition:odd-column; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-shading:#DEEAF6; mso-tstyle-shading-themecolor:accent5; mso-tstyle-shading-themetint:51;} table.MsoTable15Grid4Accent5OddRow {mso-style-name:"Tabla con cuadrícula 4 - Énfasis 5"; mso-table-condition:odd-row; mso-style-priority:49; mso-style-unhide:no; mso-tstyle-shading:#DEEAF6; mso-tstyle-shading-themecolor:accent5; mso-tstyle-shading-themetint:51;} table.MsoTable15List2 {mso-style-name:"Tabla de lista 2"; mso-tstyle-rowband-size:1; mso-tstyle-colband-size:1; mso-style-priority:52; mso-style-unhide:no; border-top:solid #666666 1.0pt; mso-border-top-themecolor:text1; mso-border-top-themetint:153; border-left:none; border-bottom:solid #666666 1.0pt; mso-border-bottom-themecolor:text1; mso-border-bottom-themetint:153; border-right:none; mso-border-top-alt:solid #666666 .5pt; mso-border-top-themecolor:text1; mso-border-top-themetint:153; mso-border-bottom-alt:solid #666666 .5pt; mso-border-bottom-themecolor:text1; mso-border-bottom-themetint:153; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-border-insideh:.5pt solid #666666; mso-border-insideh-themecolor:text1; mso-border-insideh-themetint:153; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Arial",sans-serif; mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman"; mso-ansi-language:ES; mso-fareast-language:ES-EC;} table.MsoTable15List2FirstRow {mso-style-name:"Tabla de lista 2"; mso-table-condition:first-row; mso-style-priority:52; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List2LastRow {mso-style-name:"Tabla de lista 2"; mso-table-condition:last-row; mso-style-priority:52; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List2FirstCol {mso-style-name:"Tabla de lista 2"; mso-table-condition:first-column; mso-style-priority:52; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List2LastCol {mso-style-name:"Tabla de lista 2"; mso-table-condition:last-column; mso-style-priority:52; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List2OddColumn {mso-style-name:"Tabla de lista 2"; mso-table-condition:odd-column; mso-style-priority:52; mso-style-unhide:no; mso-tstyle-shading:#CCCCCC; mso-tstyle-shading-themecolor:text1; mso-tstyle-shading-themetint:51;} table.MsoTable15List2OddRow {mso-style-name:"Tabla de lista 2"; mso-table-condition:odd-row; mso-style-priority:52; mso-style-unhide:no; mso-tstyle-shading:#CCCCCC; mso-tstyle-shading-themecolor:text1; mso-tstyle-shading-themetint:51;} table.MsoTable15List6Colorful {mso-style-name:"Tabla de lista 6 con colores"; mso-tstyle-rowband-size:1; mso-tstyle-colband-size:1; mso-style-priority:51; mso-style-unhide:no; border-top:solid black 1.0pt; mso-border-top-themecolor:text1; border-left:none; border-bottom:solid black 1.0pt; mso-border-bottom-themecolor:text1; border-right:none; mso-border-top-alt:solid black .5pt; mso-border-top-themecolor:text1; mso-border-bottom-alt:solid black .5pt; mso-border-bottom-themecolor:text1; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-fareast-font-family:Calibri; mso-bidi-font-family:"Times New Roman"; color:black; mso-themecolor:text1; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.MsoTable15List6ColorfulFirstRow {mso-style-name:"Tabla de lista 6 con colores"; mso-table-condition:first-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-border-bottom:.5pt solid black; mso-tstyle-border-bottom-themecolor:text1; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List6ColorfulLastRow {mso-style-name:"Tabla de lista 6 con colores"; mso-table-condition:last-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-border-top:1.5pt double black; mso-tstyle-border-top-themecolor:text1; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List6ColorfulFirstCol {mso-style-name:"Tabla de lista 6 con colores"; mso-table-condition:first-column; mso-style-priority:51; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List6ColorfulLastCol {mso-style-name:"Tabla de lista 6 con colores"; mso-table-condition:last-column; mso-style-priority:51; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.MsoTable15List6ColorfulOddColumn {mso-style-name:"Tabla de lista 6 con colores"; mso-table-condition:odd-column; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-shading:#CCCCCC; mso-tstyle-shading-themecolor:text1; mso-tstyle-shading-themetint:51;} table.MsoTable15List6ColorfulOddRow {mso-style-name:"Tabla de lista 6 con colores"; mso-table-condition:odd-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-shading:#CCCCCC; mso-tstyle-shading-themecolor:text1; mso-tstyle-shading-themetint:51;} table.Tablanormal41 {mso-style-name:"Tabla normal 41"; mso-tstyle-rowband-size:1; mso-tstyle-colband-size:1; mso-style-priority:99; mso-style-unhide:no; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.Tablanormal41FirstRow {mso-style-name:"Tabla normal 41"; mso-table-condition:first-row; mso-style-priority:99; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tablanormal41LastRow {mso-style-name:"Tabla normal 41"; mso-table-condition:last-row; mso-style-priority:99; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tablanormal41FirstCol {mso-style-name:"Tabla normal 41"; mso-table-condition:first-column; mso-style-priority:99; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tablanormal41LastCol {mso-style-name:"Tabla normal 41"; mso-table-condition:last-column; mso-style-priority:99; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tablanormal41OddColumn {mso-style-name:"Tabla normal 41"; mso-table-condition:odd-column; mso-style-priority:99; mso-style-unhide:no; mso-tstyle-shading:#F2F2F2; mso-tstyle-shading-themecolor:background1; mso-tstyle-shading-themeshade:242;} table.Tablanormal41OddRow {mso-style-name:"Tabla normal 41"; mso-table-condition:odd-row; mso-style-priority:99; mso-style-unhide:no; mso-tstyle-shading:#F2F2F2; mso-tstyle-shading-themecolor:background1; mso-tstyle-shading-themeshade:242;} table.Tablanormal51 {mso-style-name:"Tabla normal 51"; mso-tstyle-rowband-size:1; mso-tstyle-colband-size:1; mso-style-priority:99; mso-style-unhide:no; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.Tablanormal51FirstRow {mso-style-name:"Tabla normal 51"; mso-table-condition:first-row; mso-style-priority:99; mso-style-unhide:no; mso-tstyle-shading:white; mso-tstyle-shading-themecolor:background1; mso-tstyle-border-bottom:.5pt solid #7F7F7F; mso-tstyle-border-bottom-themecolor:text1; mso-tstyle-border-bottom-themetint:128; font-size:13.0pt; mso-ansi-font-size:13.0pt; mso-bidi-font-size:13.0pt; font-family:"Calibri Light",sans-serif; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi; mso-ansi-font-style:italic; mso-bidi-font-style:italic;} table.Tablanormal51LastRow {mso-style-name:"Tabla normal 51"; mso-table-condition:last-row; mso-style-priority:99; mso-style-unhide:no; mso-tstyle-shading:white; mso-tstyle-shading-themecolor:background1; mso-tstyle-border-top:.5pt solid #7F7F7F; mso-tstyle-border-top-themecolor:text1; mso-tstyle-border-top-themetint:128; font-size:13.0pt; mso-ansi-font-size:13.0pt; mso-bidi-font-size:13.0pt; font-family:"Calibri Light",sans-serif; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi; mso-ansi-font-style:italic; mso-bidi-font-style:italic;} table.Tablanormal51FirstCol {mso-style-name:"Tabla normal 51"; mso-table-condition:first-column; mso-style-priority:99; mso-style-unhide:no; mso-tstyle-shading:white; mso-tstyle-shading-themecolor:background1; mso-tstyle-border-right:.5pt solid #7F7F7F; mso-tstyle-border-right-themecolor:text1; mso-tstyle-border-right-themetint:128; text-align:right; font-size:13.0pt; mso-ansi-font-size:13.0pt; mso-bidi-font-size:13.0pt; font-family:"Calibri Light",sans-serif; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi; mso-ansi-font-style:italic; mso-bidi-font-style:italic;} table.Tablanormal51LastCol {mso-style-name:"Tabla normal 51"; mso-table-condition:last-column; mso-style-priority:99; mso-style-unhide:no; mso-tstyle-shading:white; mso-tstyle-shading-themecolor:background1; mso-tstyle-border-left:.5pt solid #7F7F7F; mso-tstyle-border-left-themecolor:text1; mso-tstyle-border-left-themetint:128; font-size:13.0pt; mso-ansi-font-size:13.0pt; mso-bidi-font-size:13.0pt; font-family:"Calibri Light",sans-serif; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi; mso-ansi-font-style:italic; mso-bidi-font-style:italic;} 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mso-fareast-font-family:Calibri; mso-bidi-font-family:"Times New Roman"; color:black; mso-ansi-language:ES; mso-fareast-language:EN-US;} table.Tabladelista6concolores2FirstRow {mso-style-name:"Tabla de lista 6 con colores2"; mso-table-condition:first-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-border-bottom:.5pt solid black; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tabladelista6concolores2LastRow {mso-style-name:"Tabla de lista 6 con colores2"; mso-table-condition:last-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-border-top:1.5pt double black; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tabladelista6concolores2FirstCol {mso-style-name:"Tabla de lista 6 con colores2"; mso-table-condition:first-column; mso-style-priority:51; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tabladelista6concolores2LastCol {mso-style-name:"Tabla de lista 6 con colores2"; mso-table-condition:last-column; mso-style-priority:51; mso-style-unhide:no; mso-ansi-font-weight:bold; mso-bidi-font-weight:bold;} table.Tabladelista6concolores2OddColumn {mso-style-name:"Tabla de lista 6 con colores2"; mso-table-condition:odd-column; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-shading:#CCCCCC;} table.Tabladelista6concolores2OddRow {mso-style-name:"Tabla de lista 6 con colores2"; mso-table-condition:odd-row; mso-style-priority:51; mso-style-unhide:no; mso-tstyle-shading:#CCCCCC;} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="2053"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--> </head> <body lang=ES-EC link="#0563C1" vlink="#954F72" style='tab-interval:35.4pt'> <div class=WordSection1> <h1 align=center style='text-align:center'><span style='font-size:20.0pt; font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family: "Times New Roman";mso-fareast-theme-font:major-fareast;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:major-bidi; mso-font-kerning:0pt;mso-ansi-language:ES-EC;mso-fareast-language:EN-US; mso-bidi-font-weight:normal'>La Virología y sus grandes acontecimientos</span><a style='mso-footnote-id:ftn1' href="#_ftn1" name="_ftnref1" title=""><sup><span style='font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman";mso-fareast-theme-font:major-fareast; mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi;mso-font-kerning:0pt;mso-ansi-language:ES-EC; mso-fareast-language:EN-US;mso-bidi-font-weight:normal'><span style='mso-special-character: footnote'><![if !supportFootnotes]><b style='mso-bidi-font-weight:normal'><sup><span style='font-size:24.0pt;line-height:105%;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:major-fareast;mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:major-bidi; mso-ansi-language:ES-EC;mso-fareast-language:EN-US;mso-bidi-language:AR-SA'>[1]</span></sup></b><![endif]></span></span></sup></a><sup><span style='font-size:20.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:"Times New Roman";mso-fareast-theme-font: major-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi;mso-font-kerning:0pt;mso-ansi-language:ES-EC; mso-fareast-language:EN-US;mso-bidi-font-weight:normal'> </span></sup><span style='font-size:20.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:"Times New Roman";mso-fareast-theme-font: major-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:major-bidi;mso-font-kerning:0pt;mso-ansi-language:ES-EC; mso-fareast-language:EN-US;mso-bidi-font-weight:normal'><o:p></o:p></span></h1> <h1 align=center style='text-align:center'><span lang=EN-US style='font-size: 11.0pt;font-family:"Calibri",sans-serif;mso-bidi-font-family:"Times New Roman"; mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold'>The Virology and its great developments<o:p></o:p></span></h1> <p class=ANGLES align=center style='margin:0cm;margin-bottom:.0001pt; text-align:center;line-height:normal'><span style='font-size:11.0pt;font-family: "Calibri",sans-serif;mso-bidi-font-family:"Times New Roman";mso-font-kerning: 18.0pt;mso-ansi-language:ES-EC;mso-fareast-language:ES;mso-bidi-font-weight: bold'>Coello Peralta Roberto<sup>2</sup><o:p></o:p></span></p> <p class=MsoNormal align=center style='margin-top:6.0pt;margin-right:0cm; margin-bottom:6.0pt;margin-left:0cm;text-align:center;line-height:normal; mso-pagination:none;mso-layout-grid-align:none;text-autospace:none'><span lang=ES-TRAD style='font-size:10.0pt;mso-bidi-font-family:Tahoma;color:black; mso-ansi-language:ES-TRAD'>Recibido en septiembre 2018, aceptado en abril 2019</span><span lang=ES-TRAD style='font-size:10.0pt;mso-bidi-font-family:Times;color:black; mso-ansi-language:ES-TRAD'><o:p></o:p></span></p> <p class=MsoNoSpacing style='margin-top:6.0pt;margin-right:0cm;margin-bottom: 6.0pt;margin-left:0cm;text-align:justify'><span lang=ES-TRAD style='mso-fareast-font-family: "Times New Roman";mso-ansi-language:ES-TRAD'><o:p>&nbsp;</o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;line-height:normal'><b style='mso-bidi-font-weight:normal'><span lang=ES style='font-size:10.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin; mso-fareast-language:ES'>RESUMEN<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify;line-height:normal'><span lang=EN-US style='mso-ansi-language:EN-US'>El presente es una revisión bibliográfica, acerca de grandes acontecimientos surgidos durante el estudio de los virus, desde la antigüedad hasta los actuales días. Así mismo, es de notable relevancia mencionar que el dinamismo de los virus y la aparición de nuevas metodologías de diagnósticos e innovaciones, han conllevado al surgimiento y resurgimiento de esta disciplina, de importancia en Agricultura, Vida Silvestre, Sanidad Animal, Salud Pública, entre otras.<o:p></o:p></span></p> <p class=ANGLES style='margin-top:6.0pt;line-height:normal'><b style='mso-bidi-font-weight:normal'><span lang=X-NONE style='font-size:11.0pt; font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;mso-fareast-language:ES'>Palabras clave<i style='mso-bidi-font-style:normal'>:</i></span></b><b style='mso-bidi-font-weight: normal'><i style='mso-bidi-font-style:normal'><span lang=X-NONE style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin; mso-ansi-language:ES;mso-fareast-language:ES'> </span></i></b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;mso-ansi-language:ES-EC;mso-fareast-language: EN-US'>Virología, Virus, científicos, acontecimientos. </span><b style='mso-bidi-font-weight:normal'><span lang=X-NONE style='mso-bidi-font-size: 12.0pt;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;mso-fareast-language: ES'><o:p></o:p></span></b></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;line-height:normal'><b style='mso-bidi-font-weight:normal'><span lang=EN-US style='font-size:10.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin; mso-ansi-language:EN-US;mso-fareast-language:ES'>ABSTRACT<o:p></o:p></span></b></p> <p class=MsoNormal style='text-align:justify;line-height:normal'><span lang=EN-US style='mso-ansi-language:EN-US'>This is a bibliographic review, about major events that have arisen during the study of viruses, from ancient times to the present days. Likewise, it is of remarkable relevance to mention that the dynamism of the viruses and the appearance of new methodologies of diagnoses and innovations, have led to the emergence and resurgence of this discipline, of importance in Agriculture, Wildlife, Animal Health, Public Health, among others<o:p></o:p></span></p> <p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal;mso-outline-level:1'><b style='mso-bidi-font-weight:normal'><span lang=EN-US style='mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin; mso-ansi-language:EN-US'>Key words<i style='mso-bidi-font-style:normal'>: </i></span></b><span class=tlid-translation><span lang=EN style='mso-ansi-language:EN'>Virology, Viruses, scientists, events</span><span lang=EN> </span><span lang=ES><o:p></o:p></span></span></p> <p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal;mso-outline-level:1'><span class=tlid-translation><span lang=ES><o:p>&nbsp;</o:p></span></span></p> <p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal;mso-outline-level:1'><span class=tlid-translation><span lang=ES><o:p>&nbsp;</o:p></span></span></p> <p class=ANGLES style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:36.0pt;text-indent:-18.0pt;line-height:150%;mso-list:l1 level1 lfo2'><![if !supportLists]><b style='mso-bidi-font-weight:normal'><span lang=X-NONE style='font-size:16.0pt; mso-bidi-font-size:12.0pt;line-height:150%;mso-fareast-font-family:Arial; mso-bidi-font-family:Arial;mso-fareast-language:ES'><span style='mso-list:Ignore'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp; </span></span></span></b><![endif]><b style='mso-bidi-font-weight:normal'><span lang=X-NONE style='font-size:16.0pt; mso-bidi-font-size:12.0pt;line-height:150%;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin;mso-fareast-language:ES'>Introducción</span></b><b style='mso-bidi-font-weight:normal'><span lang=X-NONE style='font-size:16.0pt; mso-bidi-font-size:12.0pt;line-height:150%;mso-bidi-font-family:Calibri; mso-bidi-theme-font:minor-latin;mso-fareast-language:ES'><o:p></o:p></span></b></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>La Virología es una ciencia rama de la biología que se encarga del estudio de los virus, los mismos que son capaces de infectar al hombre, animales, plantas e incluso bacterias y hongos. Así mismo, actualmente existen evidencias que los virus pueden infectar virus, a los que se definen como <span class=SpellE>Virófagos</span> (<span class=SpellE><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Bekliz%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=27886075"><span style='color:windowtext;text-decoration:none;text-underline:none'>Bekliz</span></a></span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Colson%20P%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=27886075"><span class=SpellE><span style='color:windowtext;text-decoration:none;text-underline: none'>Colson</span></span></a>, &amp;&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=La%20Scola%20B%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=27886075"><span style='color:windowtext;text-decoration:none;text-underline:none'>La <span class=SpellE>Scola</span></span></a>, 2016, pág. 317).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Etimológicamente, virus significa veneno en latín, según <span class=SpellE>Carballal</span> y <span class=SpellE>Oubiña</span> (2015), definen al virus como un programa, o un complejo informacional macromolecular.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Según algunos virólogos, definen a los virus de acuerdo a las siguientes características:<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Son agentes infecciosos <span class=SpellE>submicroscópicos</span> (Adamo et al, 2014, pág. 15-30).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Heterogéneos, varían en tamaño, morfología, composición química, rango de hospedadores, entre otros (Wagner, Martínez, Bloom, &amp; <span class=SpellE>Camerini</span>, 2011, pág. 1-533).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Potencialmente patógenos. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Carecen de los sistemas enzimáticos productores de energía necesaria para la síntesis de ácidos nucleicos y de proteínas.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Parásitos genéticos obligados intracelulares. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Posee un solo tipo de ácido nucleico (ADN o ARN).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Carece de organización celular (no posee ribosomas, no mitocondrias, <span class=SpellE>etc</span>). <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Y se replican por copia de su material genético (<span class=SpellE>MacLachlan</span> &amp; <span class=SpellE>Dubovi</span>, 2016, pág. 59; <span class=SpellE>Carballal</span> &amp; <span class=SpellE>Oubiña</span>, 2015, pág. 7-90).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'><o:p>&nbsp;</o:p></span></p> <p class=MsoNormal align=center style='margin-top:6.0pt;margin-right:0cm; margin-bottom:6.0pt;margin-left:0cm;text-align:center;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family: Arial;mso-no-proof:yes'><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Imagen_x0020_7" o:spid="_x0000_i1026" type="#_x0000_t75" alt="Saint Louis encephalitis virus NS1" style='width:150pt;height:150pt; visibility:visible;mso-wrap-style:square'> <v:imagedata src="listo.fld/image003.jpg" o:title="Saint Louis encephalitis virus NS1"/> </v:shape><![endif]--><![if !vml]><img border=0 width=150 height=150 src="listo.fld/image003.jpg" alt="Saint Louis encephalitis virus NS1" v:shapes="Imagen_x0020_7"><![endif]></span><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family: Arial'><o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>TOMADO DE: <a href="https://thenativeantigencompany.com/products/west-nile-virus-ns1-protein/"><span style='color:windowtext;text-decoration:none;text-underline:none'>https://thenativeantigencompany.com/products/west-nile-virus-ns1-protein/</span></a> <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>El presente describe cómo científicos/investigadores han contribuido al estudio de esta importante disciplina.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Cronología Histórica:<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Aunque no existen registros de las epidemias producidas por los virus en las épocas antiguas y medievales, muchas de estas enfermedades eran conocidas por las civilizaciones greco latinas. Sin embargo, existen evidencias arqueológicas en momias del antiguo Egipto y en antiguos grabados, que datan de 3000 años a.C., en donde muestran lesiones características de viruela y poliomielitis. <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Enfermedades como la rabia, influenza y poliomielitis también fueron conocidas por las antiguas civilizaciones (<span class=SpellE>Carballal</span> &amp; <span class=SpellE>Oubiña</span>, 2015, pág. 7-90).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Transcurrió el tiempo, hasta que en 1673 el holandés Anthony Van <span class=SpellE>Leuewenhoek</span> inventó el microscopio y así observó microbios (<span class=SpellE>Procop</span>, 2017, pág. 1951-1956).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Luego, en 1789 Eduardo <span class=SpellE>Jenner</span>, Considerado el padre de la Inmunología, inoculó costras con el virus de vaccínea a un niño de 8 años y describe de esta forma el primer método inmunológico denominado vacunación (Abbas, <span class=SpellE>Lichtman</span>, &amp; <span class=SpellE>Pillai</span>, 2016, pág. 312).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Después, para 1864 - Luís Pasteur refuta la teoría de la  generación espontánea y demuestra que las enfermedades infecciosas resultaban de la infección con microorganismos.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Dieciséis años después, Robert Koch, enuncia sus  Postulados que constituye el fundamento de la asignación etiológica de las enfermedades infecciosas. (<span class=SpellE>Procop</span>, 2017, pág. 1951-1956)<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>A continuación, en 1884 - Luis Pasteur, pasó el virus de la rabia por conejos y desarrollo la vacuna antirrábica, un gran acontecimiento para esa época (<span class=SpellE>Shors</span>, 2010, pág. 1-622).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Algo muy importante, se dio en 1886, cuando Charles Chamberlain desarrolló un filtro de porcelana que permitía retener las bacterias, pero no a otras sustancias o agentes más pequeños que podrían atravesar dichos filtros. (<span class=SpellE>Procop</span>, 2017, pág. 1951-1956).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Subsiguientemente, se presentó un acontecimiento importante en 1892, cuando Dimitri <span class=SpellE>Ivanowsky</span>, considerado el padre de la VIROLOGIA, investigando sobre la enfermedad del mosaico del tabaco (utilizando los filtros de Chamberlain), observó que de un extracto obtenido de la maceración de hojas infectadas era capaz de transmitir la enfermedad; este investigador atribuyó a las toxinas producida por las bacterias que podrían atravesar filtros, a lo que se refirió a fluidos infectantes, pero más tarde se conoció que esta infección se debía al virus del mosaico del tabaco. A <span class=SpellE>Ivanowsky</span> se lo considera el padre de la Virología.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Entre 1897  1898, Friedrich <span class=SpellE>Loeffler</span> y Paúl <span class=SpellE>Frosch</span> descubren el virus con afectación animal, llamado virus de la fiebre aftosa (<span class=SpellE>MacLachlan</span> &amp; <span class=SpellE>Dubovi</span>, 2016, pág. 59).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>También un hecho importante se llevó acabo en 1898, cuando <span class=SpellE>Martinus</span> <span class=SpellE>Beijernick</span>, muele las hojas de plantas enfermas, lo pasa por filtros de membrana y el contenido de la filtración lo infecta en plantas sanas, describe el termino de Virus filtrable y habla del contagio in vivo de un virus vegetal (Virus del Mosaico del Tabaco). (<span class=SpellE>Procop</span>, 2017, pág. 1951-1956).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Cuatro años después, Walter Reed Realizó importantes investigaciones sobre: la&nbsp;<a href="https://www.ecured.cu/Etiolog%C3%ADa" title=Etiología><span style='color:windowtext;text-decoration:none;text-underline:none'>etiología</span></a>, control y transmisión de la Fiebre amarilla.<span style='mso-spacerun:yes'>  </span><o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Otro acontecimiento destacable se dio en 1908, cuando <span class=SpellE>Landteiner</span> y Popper, transmiten el virus polio del hombre al mono (<span class=SpellE>transmision</span> experimental), siendo uno de los sistemas biológicos para replicar virus en el laboratorio (<span class=SpellE>Shors</span>, 2010, pág. 1-622). <o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>En el mismo año <span class=SpellE>Ellerman</span> y <span class=SpellE>Bang</span> descubren virus en leucemias de pollo, luego en 1911 <span class=SpellE>Francys</span> <span class=SpellE>Peyton</span> <span class=SpellE>Rous</span>, utiliza por primera vez embrión de pollo, que es otro sistema <span class=SpellE>biologíco</span> para replicar virus en el laboratorio, describiendo de esta forma el virus del sarcoma de <span class=SpellE>Rous</span> y en 1966 este último, recibe el premio nobel por el descubrimiento de virus tumorales (<span class=SpellE>Cabasso</span>, 1967, pág. 51-57; <span class=SpellE>MacLachlan</span> &amp; <span class=SpellE>Dubovi</span>, 2016, pág. 59).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Luego, Frederick <span class=SpellE>Twort</span>, un <span class=SpellE>bacteriologo</span> <span class=SpellE>britanico</span> en 1915 accidentalmente observó el efecto de ciertos filtrados sobre las bacterias y dos años más tarde en 1917, <span class=SpellE>Felix</span> <span class=SpellE>D Herelle</span> describió que estos infiltrados atacaban bacterias y los denominó bacteriófagos; ambos descubrieron los <span class=SpellE>bacteriofagos</span> (<span class=SpellE>MacLachlan</span> &amp; <span class=SpellE>Dubovi</span>, 2016, pág. 59).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>A continuación, entre 1925 a 1930, <a href="https://es.wikipedia.org/wiki/Ernst_Ruska" title="Ernst Ruska"><span style='color:windowtext;text-decoration:none;text-underline:none'>Ernst <span class=SpellE>Ruska</span></span></a>&nbsp;y&nbsp;<a href="https://es.wikipedia.org/wiki/Max_Knoll"><span style='color:windowtext; text-decoration:none;text-underline:none'>Max <span class=SpellE>Knoll</span></span></a> construyen el microscopio electrónico, el mismo que permite una&nbsp;amplificación de más de 1200 veces el tamaño de muestra original (<span class=SpellE>Amano</span> &amp; Díaz, 2015, pág. 15-30).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Subsiguientemente, utilizando el microscopio electrónico, <span class=SpellE>Wendell</span> Stanley en 1935 (Premio nobel) realizó el aislamiento, purificación y cristalización del virus del mosaico del tabaco (<span class=SpellE>Tabamovirus</span>) (Le, 1986, pág. 450-472).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Así mismo, en este último año, Max <span class=SpellE>Theiler</span> y Smith, (Premios nobel) <span class=SpellE>obtuveron</span> la vacuna contra el virus de la fiebre amarilla (<span class=SpellE>Theiler</span>&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Smith%20HH%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=19870634"><span style='color:windowtext;text-decoration:none;text-underline:none'>&amp; Smith,</span></a> 1937, pág. 787-800).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Un año después<a href="https://www.cdc.gov/vaccines/pubs/pinkbook/flu.html"><span style='color:windowtext;text-decoration:none;text-underline:none'>, <span class=SpellE>Burnet</span> descubre que se puede replicar el virus de influenza en embriones de huevos de gallinas.</span></a> (CDC, 2019, pág. 1-3). Y en 1940 G. K. <span class=SpellE>Hirst</span>, descubrió que el virus de influenza se aglutina alrededor de los <span class=SpellE>globulos</span> rojos, lo que se conoce como Hemaglutinación (López, 1963, pág. 945-951).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>En 1943 <span class=SpellE>Huang</span> descubrió cambios necróticos (efectos <span class=SpellE>citopáticos</span>) en células embrionarias de pollo, inoculados con el virus de encefalitis equina.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Pero otro hecho trascendental en la historia de la virología, se dio en 1949, cuando John F. <span class=SpellE>Enders</span>, Thomas <span class=SpellE>Weller</span> y Frederick <span class=SpellE>Robbins</span> (Premios nobel) describieron el cultivo del virus de la poliomielitis, posteriormente entre 1950 a 1960 muchos otros virus se cultivaron utilizando los mismos principios, lo que dio origen al tercer sistema biológico de replicación viral que son los cultivos celulares.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Entre 1952-1955 ante la presencia de la Pandemia de la Poliomielitis, <span class=SpellE>Jonas</span> <span class=SpellE>Salk</span>, logró obtener la primera vacuna contra la Poliomielitis (intramuscular), a través de virus inactivados o muertos. Luego en 1957- Albert <span class=SpellE>Seivin</span>, obtuvo la segunda Vacuna contra la <span class=SpellE>Poliomietitis</span> (oral) obtenida de virus vivo (atenuados).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Después, en 1956, Watson y Crick (1956) realizaron descubrimientos concernientes a la estructura molecular de los ácidos desoxirribonucleicos (ADN) y su importancia para la transferencia de información en la materia viva (Leonard et al, 1986, pág. 255-265).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>En 1959 <span class=SpellE>Brenner</span> y <span class=SpellE>Horne</span> desarrollaron la tinción negativa, con la cual se podría diferenciar las estructuras internas de los virus (<span class=SpellE><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=BRENNER%20S%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=13804200"><span style='color:windowtext;text-decoration:none;text-underline:none'>Brenner</span></a></span>&nbsp;&amp; <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=HORNE%20RW%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=13804200"><span class=SpellE><span style='color:windowtext;text-decoration:none;text-underline: none'>Horne</span></span><span style='color:windowtext;text-decoration:none; text-underline:none'>,</span></a> 1959, pág. 103-110).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Por otro lado, en 1962 - &nbsp;<a href="https://es.wikipedia.org/wiki/Howard_Temin" title="Howard Temin"><span style='color:windowtext;text-decoration:none; text-underline:none'>Howard <span class=SpellE>Temin</span></span></a>&nbsp;y&nbsp;<a href="https://es.wikipedia.org/wiki/David_Baltimore"><span style='color:windowtext; text-decoration:none;text-underline:none'>David Baltimore</span></a>, describieron la transcripción inversa, la misma que contradice el&nbsp;<a href="https://es.wikipedia.org/wiki/Dogma_central_de_la_biolog%C3%ADa_molecular" title="Dogma central de la biología molecular"><span style='color:windowtext; text-decoration:none;text-underline:none'>dogma central de la biología molecular</span></a>, que establece que el ADN se transcribe en ARN. En ese mismo año, Los investigadores <span class=SpellE>Francois</span> Jacob, André <span class=SpellE>Lwoff</span> y Jacques <span class=SpellE>Monod</span> (premios nobel) realizan la descripción de <span class=SpellE>operones</span> y <span class=SpellE>bacteriofagos</span>; así mismo en MARBURGO (Alemania), se describe el Virus del <span class=SpellE>marburgo</span> causante de fiebres hemorrágicas con alta tasa de mortalidad en humanos.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Luego, en 1966 en <span class=SpellE>Moscu</span> se establece el Comité Internacional de Nomenclatura de los virus, que es el órgano que autoriza y organiza la clasificación&nbsp;<a href="https://es.wikipedia.org/wiki/Taxonom%C3%ADa" title=Taxonomía><span style='color:windowtext;text-decoration:none;text-underline: none'>taxonómica</span></a>&nbsp;de los&nbsp;<a href="https://es.wikipedia.org/wiki/Virus" title=Virus><span style='color:windowtext; text-decoration:none;text-underline:none'>virus</span></a> (ICTV, 2018, pág. 5-13).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Después, en 1969 Max <span class=SpellE>Delbruck</span>, Alfred <span class=SpellE>Hersey</span> y Salvador Luria, (premios nobel) describieron el mecanismo de infección de los <span class=SpellE>bacteriofagos</span> en células.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Otro hecho importante en la virología, fue cuando David Baltimore, Howard <span class=SpellE>Temin</span> y Renato <span class=SpellE>Dulbeco</span> (premios nobel) en 1975 realizaron el descubrimiento de la interacción entre los virus tumorales (<span class=SpellE>Retroviridae</span>) y el genoma celular (<span class=SpellE>Shors</span>, 2010, pág. 1-622).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>En 1976 aparece el Virus del <span class=SpellE>ebola</span>, en dos brotes simultáneos ocurridos en <span class=SpellE>Nzara</span> (hoy Sudán del Sur) y <span class=SpellE>Yambuku</span> (República Democrática del Congo), la aldea en que se produjo el segundo de ellos está situada cerca del río <span class=SpellE>Ebola</span>, que da nombre al virus, el mismo, que cuenta con una taza de mortalidad del 90% (OMS, 2018, pág. 1-3). Así mismo, en el mismo año D. <span class=SpellE>Carleton</span> <span class=SpellE>Gajdusek</span> y Baruch <span class=SpellE>Blumberg</span> (premios nobel) descubrieron los priones y los <span class=SpellE>Hepadniviridae</span>, respectivamente (<span class=SpellE>Shors</span>, 2010, pág. 1-622).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Por otro lado, en 1977-Roberto Gallo, Descubre los virus leucémicos, HTLV1 Y HTLV2 (Virus <span class=SpellE>linfotropicos</span> Humanos) y es considerado el padre de los Retrovirus.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>En 1978, Daniel <span class=SpellE>Nathans</span> (premio nobel) describió el uso de las enzimas de restricción en el estudio de la genética del virus SV-40 (<span class=SpellE>Poliomaviridae</span>).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Dos años siguientes, el premio nobel Paúl <span class=SpellE>Berg</span> en 1980 realizó la recombinación de ácidos nucleicos e inserción de genes (<span class=SpellE>Poliomaviridae</span>) y en 1986 se produce las primeras vacunas por <span class=SpellE>ingenieria</span> genética, que es la vacuna contra el virus de la hepatitis B (<span class=SpellE>Shors</span>, 2010, <span class=GramE>pág. ;</span> R&amp;D <span class=SpellE>Systems</span>, 2018, pág. 1-3).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Así mismo, a comienzo de los 80 apareció un virus pandémico desconocido, que en 1984 el Dr. Roberto Gallo lo publicó como HTLV 3, y posteriormente el equipo de <span class=SpellE>Luc</span> <span class=SpellE>Montanier</span> lo describió como virus LAV (virus asociado a <span class=SpellE>linfoadenopatia</span> generalizada). Ante esta controversia, en 1986 un comité de expertos lo denominaron virus del VIH, causante del SIDA (<span class=SpellE>Shors</span>, 2010, pág. 1-622).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>En 1982 <span class=SpellE>Aaron</span> <span class=SpellE>Klung</span> (premio nobel) efectuó la determinación de la estructura de complejos de ácidos nucleicos y proteínas por cristalografía y microscopía electrónica. (<span class=SpellE>Tobamovirus</span> y <span class=SpellE>Tymmovirus</span>).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Por otro lado, los científicos George <span class=SpellE>Hitching</span> y <span class=SpellE>Gertrude</span> <span class=SpellE>Elion</span> (premios nobel) en 1988, realizó los principios del desarrollo de antivirales (<span class=SpellE>aciclovir</span>).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Un año después en 1989 Michael <span class=SpellE>Bishop</span> y Harold <span class=SpellE>Varnus</span> (premios nobel), realizó el descubrimiento del origen celular de los oncogenes (<span class=SpellE>Retroviridae</span>).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Posteriormente, en 1984 se desarrollaron los anticuerpos monoclonales por <a href="https://es.wikipedia.org/wiki/Niels_K._Jerne" title="Niels K. Jerne"><span style='color:windowtext;text-decoration:none;text-underline:none'>Niels K. <span class=SpellE>Jerne</span></span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Georges_K%C3%B6hler"><span style='color:windowtext;text-decoration:none;text-underline:none'>Georges <span class=SpellE>Köhler</span></span></a>&nbsp;y&nbsp;<a href="https://es.wikipedia.org/wiki/Cesar_Milstein" title="Cesar Milstein"><span style='color:windowtext;text-decoration:none;text-underline:none'>Cesar <span class=SpellE>Milstein</span></span></a>, los mismos que se utilizan para tratamiento y diagnóstico de diversas enfermedades.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>A continuación, en 1993, <span class=SpellE>Phill</span> Sharp y Richards Roberts (premios nobel) descubrieron la discontinuidad de los genes (<span class=SpellE>Splicing</span>) utilizando un Adenovirus causante del resfriado.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Para 1996, <span class=SpellE>Rolf</span> <span class=SpellE>Zinkernagel</span> y Peter <span class=SpellE>Doherty</span> (Premios nobel) describieron la presentación de los antígenos virales a los sistemas mayores de histocompatibilidad. </span><span lang=EN-US style='mso-bidi-font-size:10.0pt; line-height:150%;mso-bidi-font-family:Arial;mso-ansi-language:EN-US'>(<span class=SpellE>Shors</span>, 2010, <span class=SpellE>pág</span>. 1-622; <span class=SpellE>Carballal</span> G., &amp; <span class=SpellE>Oubiña</span>, 2015, <span class=SpellE>pág</span>. 7-90; R&amp;D Systems, 2018, pág.1-3)<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Después, Stanley <span class=SpellE>Prusiener</span> (premio nobel) en 1999, realizó la caracterización de los priones; en el mismo año apareció por primera vez el Virus del Nilo Occidental en New York (EEUU), donde produjo muchas epizootias y epidemias (<span class=SpellE>Enquist</span>, 2009, <span class=GramE>pág. ;</span> R&amp;D <span class=SpellE>Systems</span>, 2018, pág. 1-3).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Por otro lado, desde el año 2000 en adelante se presentaron, <span class=GramE>varios acontecimientos entre ellos se destaca</span>: En el 2003 el Centro de Control y Prevención de Enfermedades (CDC) y el laboratorio de Microbiología del hospital Nacional de <span class=SpellE>Canada</span> identificaros el virus causarte del <span class=SpellE>sindrome</span> agudo respiratorio severo (SARS). Luego en el 2006 se crean las vacunas contra el Rotavirus y el Virus del Papiloma Humano (<span class=SpellE>Enquist</span>, 2009, pág. 5296-5308; R&amp;D <span class=SpellE>Systems</span>, 2018, pág. 1-3).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Para el 2008 se descubrieron virus que infectan virus gigantes en las mismas células eucariotas, a los que se denominaron, <span class=SpellE>Virofagos</span>, que miden de 35 a 74 nanómetros (<span class=SpellE>nm</span>), poseen <span class=SpellE>cápsides</span> con simetría <span class=SpellE>icosaédrica</span> y genomas de ADN <span class=SpellE>bicatenario</span> grandes de 17 a 29 <span class=SpellE>kilopares</span> de bases (<span class=SpellE>kbp</span>) con 16 a 34 genes (<span class=SpellE>Bekliz</span>, 2016, pág. 317).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Otro acontecimiento, fue el que aconteció en el 2009 donde se apareció la pandemia mundial llamada influenza porcina, causada por el virus de influenza A H1N1, este virus poseía genes aviar, del cerdo y humano. El virus salto la barrera de especies, <span class=SpellE>transmitiendose</span> de los animales a humanos; luego el virus se extendió de humano a humano por el <span class=GramE>mundo<span style='mso-spacerun:yes'>  </span>(</span><span class=SpellE>Enquist</span>, 2009, pág. 5296-5308; R&amp;D <span class=SpellE>Systems</span>, 2018, pág. 1-3).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Para el 2011, la Organización Mundial de Sanidad (OMS) declaró oficialmente libre de peste bovina, luego en el 2012 se detectó el coronavirus causante del síndrome respiratorio del Medio Oriente (MERS) con posible transmisión de camellos a humanos.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Por otro lado, en la Región de las Américas en diciembre de 2013, se detectó por primera vez la transmisión autóctona del virus <span class=SpellE>Chikungunya</span>. A partir de esa fecha y hasta el 30 de mayo del 2014, la Organización Panamericana de la Salud (OPS) notificaron 4,406 casos confirmados en 18 países.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Otro hecho se dio, entre 2014 al 2016, donde apareció el mayor&nbsp;<a href="https://es.wikipedia.org/wiki/Brote_epid%C3%A9mico" title="Brote epidémico"><span style='color:windowtext;text-decoration:none; text-underline:none'>brote epidémico</span></a>&nbsp;de la&nbsp;<a href="https://es.wikipedia.org/wiki/Enfermedad_por_el_virus_del_%C3%89bola" title="Enfermedad por el virus del Ébola"><span style='color:windowtext; text-decoration:none;text-underline:none'>enfermedad por el virus del <span class=SpellE>Ébola</span></span></a>, y extendido posteriormente a&nbsp;<a href="https://es.wikipedia.org/wiki/Liberia" title=Liberia><span style='color:windowtext;text-decoration:none;text-underline:none'>Liberia</span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Sierra_Leona" title="Sierra Leona"><span style='color:windowtext;text-decoration:none;text-underline:none'>Sierra Leona</span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Nigeria" title=Nigeria><span style='color:windowtext;text-decoration:none;text-underline:none'>Nigeria</span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Senegal" title=Senegal><span style='color:windowtext;text-decoration:none;text-underline:none'>Senegal</span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Estados_Unidos" title="Estados Unidos"><span style='color:windowtext;text-decoration:none;text-underline:none'>Estados Unidos</span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Espa%C3%B1a" title=España><span style='color:windowtext;text-decoration:none;text-underline: none'>España</span></a>,&nbsp;<a href="https://es.wikipedia.org/wiki/Mal%C3%AD" title=Malí><span style='color:windowtext;text-decoration:none;text-underline: none'>Malí</span></a>&nbsp;y&nbsp;<a href="https://es.wikipedia.org/wiki/Reino_Unido" title="Reino Unido"><span style='color:windowtext;text-decoration:none;text-underline:none'>Reino Unido</span></a>.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Después, entre 2015 y 2016 apareció en Brasil el virus <span class=SpellE>Zika</span> y luego se diseminó por muchos países alcanzando niveles pandémicos (<span class=SpellE>Enquist</span>, 2009, pág. 5296-5308; R&amp;D <span class=SpellE>Systems</span>, 2018, pág. 1-3).<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><span lang=ES style='mso-bidi-font-size:10.0pt;line-height:150%;mso-bidi-font-family:Arial'>Finalmente, es importante mencionar que ante los notables progresos científicos en el mundo (diagnóstico, prevención y otros), los virus siguen desafiando al mundo, con aparición de virus antiguos (reemergentes) y nuevas virosis (emergentes), por lo consiguiente, es notable su estudio y seguir evolucionando en <span class=SpellE>metodologias</span> diagnósticas y de control y prevención.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0cm;margin-bottom:6.0pt; margin-left:0cm;text-align:justify;line-height:150%'><b style='mso-bidi-font-weight: normal'><span lang=ES style='font-size:16.0pt;mso-bidi-font-size:11.0pt; line-height:150%;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin'>Referencias bibliográficas<o:p></o:p></span></b></p> <w:Sdt Bibliography="t" ID="111145805"> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'>Abbas, A., Lichtman, A., &amp; Pillai, S. (2016). Inmunología celular y molecular. Octava edición. En Libro de Inmunología (pág. 312). Barcelona-España: ELSEVIER. <o:p></o:p></span></i><span lang=ES><w:sdtPr></w:sdtPr></span></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'>Adamo, M. et al. (2014). Virología Médica In Vivo. Primera edición. En Libro de Virología (pág. 434- 436). Córdoba-Argentina: BRUJAS <o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'>Amano, Y. J., &amp; Díaz, L. (2015). Introducción a la Microscopía Electrónica: Principios-Aplicaciones. Tercera edición. En Libro de Microscopía Electrónica (pág. 15-30). Guayaquil-Ecuador: INSPI.<o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Bekliz%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=27886075"><span style='color:windowtext;text-decoration:none;text-underline:none'>Bekliz</span></a>, M.,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Colson%20P%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=27886075"><span style='color:windowtext;text-decoration:none;text-underline:none'>Colson</span></a>, P., &amp;&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=La%20Scola%20B%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=27886075"><span style='color:windowtext;text-decoration:none;text-underline:none'>La Scola</span></a>, B. (2016). </span></i><i><span lang=EN-US style='mso-ansi-language:EN-US; mso-no-proof:yes'>The Expanding Family of Virophages. En Artículo científico de Rev. Viruses, 8 (11). (pág. 317).<o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=BRENNER%20S%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=13804200"><span lang=EN-US style='color:windowtext;mso-ansi-language:EN-US;text-decoration: none;text-underline:none'>Brenner, S</span></a></span></i><i><span lang=EN-US style='mso-ansi-language:EN-US;mso-no-proof:yes'>.,&nbsp;&amp; </span></i><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=HORNE%20RW%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=13804200"><span lang=EN-US style='color:windowtext;mso-ansi-language:EN-US;text-decoration: none;text-underline:none'>Horne, R. W</span></a></span></i><i><span lang=EN-US style='mso-ansi-language:EN-US;mso-no-proof:yes'>. (1959). A negative staining method for high resolution electron microscopy of viruses. </span></i><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'>En Artículo científico de Rev. <a href="https://www.ncbi.nlm.nih.gov/pubmed/13804200" title="Biochimica et biophysica acta."><span style='color:windowtext; text-decoration:none;text-underline:none'>Biochim Biophys Acta</span></a>, 34(1). (pág. 103-110).<o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'>Cabasso, V. (1967). Algunos progresos en Virología. En Artículo científico de la Academia Nacional de Agronomía y Veterinaria. Buenos Aires-Argentina, 6 (1). (pág. 51-57). 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Virology in the 21st Century. </span></i><i><span lang=ES-TRAD style='mso-ansi-language: ES-TRAD;mso-no-proof:yes'>En Artículo científico de Rev. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681991/"><span style='color:windowtext;text-decoration:none;text-underline:none'>J Virol</span></a>, 83(11). (pág. 5296 5308).<o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'>International Committe on Taxonomy of Viruses (ICTV). 2018. Information. En línea, (pág. 5-13). </span></i><i><span lang=EN-US style='mso-ansi-language:EN-US; mso-no-proof:yes'>Recuperado de: </span></i><i><span lang=ES-TRAD style='mso-ansi-language:ES-TRAD;mso-no-proof:yes'><a href="https://talk.ictvonline.org/information/"><span lang=EN-US style='color:windowtext;mso-ansi-language:EN-US;text-decoration:none; text-underline:none'>https://talk.ictvonline.org/information/</span></a></span></i><i><span lang=EN-US style='mso-ansi-language:EN-US;mso-no-proof:yes'><o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><i><span lang=EN-US style='mso-ansi-language:EN-US;mso-no-proof:yes'>Le, K., (1986). W. M. 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(pág. 1-533): Blackwell Publishing.<o:p></o:p></span></i></p> <p class=MsoBibliography style='margin-left:36.0pt;text-indent:-36.0pt'><span lang=ES><o:p>&nbsp;</o:p></span></p> <p class=MsoNormal style='line-height:normal'><span lang=ES><o:p>&nbsp;</o:p></span></p> </w:Sdt> <p class=MsoNormal style='margin-top:0cm;margin-right:0cm;margin-bottom:0cm; margin-left:35.45pt;margin-bottom:.0001pt;text-indent:-35.45pt'><span lang=ES style='mso-no-proof:yes'><o:p>&nbsp;</o:p></span></p> </div> <div style='mso-element:footnote-list'><![if !supportFootnotes]><br clear=all> <hr align=left size=1 width="33%"> <![endif]> <div style='mso-element:footnote' id=ftn1> <p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align: justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none'><a style='mso-footnote-id:ftn1' href="#_ftnref1" name="_ftn1" title=""><span class=MsoFootnoteReference><span lang=ES style='font-size:9.0pt;mso-bidi-font-family: Calibri;mso-bidi-theme-font:minor-latin'><span style='mso-special-character: footnote'><![if !supportFootnotes]><span class=MsoFootnoteReference><span lang=ES style='font-size:9.0pt;line-height:105%;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin; mso-ansi-language:ES;mso-fareast-language:EN-US;mso-bidi-language:AR-SA'>[1]</span></span><![endif]></span></span></span></a><span lang=ES style='font-size:9.0pt;mso-bidi-font-family:Calibri;mso-bidi-theme-font: minor-latin'> </span><span lang=ES style='font-size:9.0pt;mso-fareast-font-family: Arial;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin'>Artículo original derivado del proyecto de investigación FCI de la Universidad de Guayaquil, titulado:  </span><span class=SpellE><span lang=ES style='font-size: 9.0pt;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;color:black'>Ecoepidemiología</span></span><span lang=ES style='font-size:9.0pt;mso-bidi-font-family:Calibri;mso-bidi-theme-font: minor-latin;color:black'> del Virus de Encefalitis Equina del Este, en 2 sectores de las zonas 5 y 8 de las provincias del Guayas y los Ríos, república del Ecuador </span><span lang=ES style='font-size:9.0pt;mso-fareast-font-family: Arial;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin'>- Entidad financiadora: Universidad de Guayaquil, fecha de realización entre <span class=GramE>Enero</span> a Junio del 2019</span><span lang=ES style='font-size: 9.0pt;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin'><o:p></o:p></span></p> <p class=MsoFootnoteText style='text-align:justify'><span class=MsoFootnoteReference><span style='font-size:9.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin;mso-ansi-language:ES-EC'>2</span></span><span style='font-size: 9.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin;mso-ansi-language: ES-EC'> </span><span style='font-size:9.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Arial;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;mso-ansi-language:ES-EC'>Médico Veterinario y Zootecnista, Magíster en Microbiología con mención Biomédica, Coordinador de Investigación de la FMVZ de la Universidad de Guayaquil, roberto.coellope@ug.edu.ec, </span><span style='font-size:9.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin;mso-ansi-language:ES-EC'>https://orcid.org/</span><span lang=EN-US style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'><a href="http://orcid.org/0000-0001-5152-2843"><span lang=ES-TRAD style='color:windowtext;mso-ansi-language:ES-EC'><span lang=ES-TRAD>0000-0001-5152-2843</span></span></a></span><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin; mso-ansi-language:ES-EC'>, ID: 60072042</span><span style='font-family:"Arial Narrow",sans-serif; mso-fareast-font-family:Arial;mso-bidi-font-family:Arial;mso-ansi-language: ES-EC'><o:p></o:p></span></p> </div> </div> </body> </html>

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